Figure 1 from The fission yeast cytokinetic ring component Fic1 Biology Diagrams ZipA and FtsA have partially overlapping roles in stimulating Z-ring formation in E. coli, but ZipA has a specific function in promoting pre-septal FtsZ-directed PG synthesis [50 A flexible C-terminal linker is required for proper FtsZ assembly in vitro and cytokinetic ring formation in vivo. Mol Microbiol (2013), 10.1111/mmi.12272. Google
The PCH family protein, Cdc15p, recruits two F-actin nucleation pathways to coordinate cytokinetic actin ring formation in Schizosaccharomyces pombe. J Cell Biol. 2003;162:851-862. doi: 10.1083/jcb.200305012. [PMC free article] [Google Scholar] 22. Dong Y, Pruyne D, Bretscher A. Formin-dependent actin assembly is regulated by distinct modes
Cytokinesis: Rho and Formins Are the Ringleaders Biology Diagrams
Animal cells, amoebas and yeast divide using a force-generating, actin- and myosin-based contractile ring or 'cytokinetic ring' (CR). Despite intensive research, questions remain about the spatial organization of CR components, the mechanism by which the CR generates force, and how other cellular processes are coordinated with the CR for successful membrane ingression and ultimate cell For example, mid1ฮ cells are viable and are still able to form a cytokinetic ring via a leading cable-like process, though there does not appear to be any mechanism to direct ring formation to the cell middle, as these rings are often misplaced and not orthogonal to the long axis 38, 54, 55 (although inhibition of septum synthesis can allow
Formation of the cytokinetic ring also requires IQGAP proteins, a family of proteins that have an IQ domain, a GTPase activation domain and an actin-binding calponin homology domain. The IQGAP protein Cyk1p/Iqg1p is required to recruit actin to the site of cytokinesis in response to signaling events . Formation of the cytokinetic ring also requires IQGAP proteins, a family of proteins that have an IQ domain, a GTPase activation domain and an actin-binding calponin homology domain. The IQGAP protein Cyk1p/Iqg1p is required to recruit actin to the site of cytokinesis in response to signaling events 7., 8..
Mechanisms of contractile ring tension production and constriction Biology Diagrams
I will use this review on the molecular mechanism of cytokinesis to highlight what we do not know. I focus on the contractile ring of actin filaments and myosin-II, which drives the formation of the cytokinetic furrow in animals, fungi, and amoebas. Nine questions, most posed 40 to 50 yr ago, remain unanswered or incompletely understood (Fig. 1 Animal cells, amoebas and yeast divide using a force-generating, actin- and myosin-based contractile ring or 'cytokinetic ring' (CR). Despite intensive research, questions remain about the spatial organization of CR components, the mechanism by which the CR generates force, and how other cellular processes are coordinated with the CR for successful membrane ingression and ultimate cell separation.
